Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma.
نویسنده
چکیده
The association of nasopharyngeal carcinoma (NPC) with the Epstein-Barr virus (EBV) was firmly established as early as 1973. Nevertheless, the role for the virus in the pathogenesis of NPC is still controversial. In this article, the evidence implicating EBV in the development of NPC is reviewed, focusing on the cellular site of EBV persistence, the association of the virus with different NPC histotypes, the tumour cell phenotype in the context of viral latent gene expression, and the possible role of the lymphoid stroma.
منابع مشابه
تعیین میزان همراهی ویروس اپشتین-بار با سرطان نازوفارنکس توسط روش واکنش زنجیره ای پلیمراز
Background and purpose: The association of nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) was firmly established as early as 1973. A clear understanding of its etiology is still lacking, but nasopharyngeal carcinoma is widely suspected to be the result of both a genetic susceptibility and exposure to environmental factors or Epstein-Barr virus infection. NPC is more prevalent in yo...
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عنوان ژورنال:
- Der Pathologe
دوره 19 5 شماره
صفحات -
تاریخ انتشار 1998